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| Id: | 21750
| | Autor: | McKean, J. Hugh. | | Título: | Limitations of the diphtheria toxoid treatment of leprosy.
| | Fonte: | Int. J. Lepr;9(3):309-314, July-Sept. 1941. .
| | Resumo: | One of the first things noted when diphtheria toxoid was first used in the treatment of leprosy at Chiengmai was the wide variation in the response to this treatment in cases of the same classification. This has been especially true of lepromatous cases of moderate and marked degrees of advancement (L2 and L3). The best results were seen in major tuberculoid cases which were bacteriologically negative, and in early lepromatous (L1) cases also showed excellent results, but the relapse of three of 21 cases rendered negative suggested that further observation is needed with regard to the permanence of such improvement. The treatment has been of no value in major tuberculoid cases with numerous bacilli, or in the papular type of lepromatous cases. Minor tuberculoid cases in which lesions appear to be active, though bacteriologically negative, ahve also failed to respond. Those cases in which favorable results appaear early--i.e., after one or two injections of toxoid, given at two-week intervals--derive the maximun benefit from the treatment. There is a tendency to relapse, and in such cases the benefits of further treatment are generally temporary, as regards the relief of nerve pain and the control of lepra reactions. In such cases, too, the gradual subsidence of active lesions after an injection of toxoid is commonly accompanied by the development of new activity in another part of the body. The maximum dose has been empirically set at 3 cc. Accidents have been avoided by never exceeding that amount. Bacteriological examinations revealed that 38 of 286 patients under toxoid treatment showed unusually marked fragmentation of bacilli. (AU).
| | Descritores: | HANSENIASE/quimioter
TOXOIDE DIFTERICO/farmacol
TOXOIDE DIFTERICO/uso terap
| | Limites: | HUMANO
| | Localização: | BR191.1 |
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